A novel control condition for spatial learning in the Morris water maze
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چکیده
منابع مشابه
CaMKII binding to GluN2B is important for massed spatial learning in the Morris water maze
Learning and memory as well as long-term potentiation (LTP) depend on Ca (2+) influx through the NMDA-type glutamate receptor (NMDAR) and the resulting activation of the Ca (2+) and calmodulin-dependent protein kinase (CaMKII). Ca (2+) influx via the NMDAR triggers CaMKII binding to the NMDAR for enhanced CaMKII accumulation at post-synaptic sites that experience heightened activity as occurrin...
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Synaptic plasticity at hippocampal excitatory synapses has been proposed as the cellular mechanism underlying spatial learning and memory. However, most previous studies have focused on the role of long-term potentiation (LTP) in learning and memory, and much less is known about the role of long-term depression (LTD). Here, we report that hippocampal-dependent spatial learning in the Morris wat...
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ژورنال
عنوان ژورنال: Journal of Neuroscience Methods
سال: 2019
ISSN: 0165-0270
DOI: 10.1016/j.jneumeth.2019.02.015